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UT Zika research leading global efforts
As the Zika virus continues to spread around the world, Latin American countries most affected by the mosquito-borne disease are employing the expertise of researchers at The University of Texas Medical Branch in Galveston to fight the deadly epidemic.
The Brazilian Ministry of Health is collaborating with UTMB faculty researchers to develop a Zika vaccine. UTMB will be working with Cuban scientists at Instituto Pedro Kouri in Havana on a two-year research development program to combat infectious diseases such as Zika.
UTMB’s world-class researchers and facilities — including the Institute for Human Infections and Immunity and The World Reference Center for Emerging Viruses and Arboviruses — are global leaders in the fight against Zika.
Several other University of Texas System institutions also have increased efforts to study and combat Zika, which has triggered fear in the United States as mosquito season ramps up.
“The UT System is leading the way on multiple fronts to knock out this virus,” said David Lakey, M.D., the System’s chief medical officer. “This situation demands urgency, as the mosquitoes that spread Zika are most active during the summer.”
Lakey recently was selected to help plan and present at a workshop convened by the National Academies of Sciences, Engineering and Medicine to discuss and explore the key factors associated with the Zika virus. The workshop came at the request of the U.S. Department of Health and Human Services' Assistant Secretary for Preparedness and Response.
UT System institutions’ efforts against this vexing virus advances The UT Health Care Enterprise, one of eight bold strategic initiatives described as Quantum Leaps, launched last year by UT System Chancellor William H. McRaven. This particular initiative aims to improve the health of Texans.
“We are leveraging our size and expertise to understand Zika at its fundamental level and disseminate the best and most timely information to help state, local and federal agencies fight this terrible virus,” McRaven said.
Cloning, Brain Cells and Algae
In one of the biggest Zika research breakthroughs to date , a team of UTMB researchers became the first scientists in the world to genetically engineer a clone of the Zika virus strain. This groundbreaking discovery could speed up many aspects of Zika research, including the development of vaccines and treatments.
“The new Zika clone represents a major advance toward deciphering why the virus is tied to serious diseases,” said Pei-Yong Shi, Ph.D., a UTMB professor who led the clone study.
Another important finding occurred when researchers from UT Southwestern discovered that Zika directly infects brains cells and evades immune system detection.
The study shows that the virus — linked to microcephaly and other birth defects in newborns — infects brain cells destined to become neurons, according to UTSW microbiologist John Schoggins, Ph.D., the study’s senior author. This scientific knowledge is invaluable to further understand how Zika causes severe brain-related problems.
Meanwhile, several Latin American countries have issued health advisories and warnings to women to avoid pregnancy because of the Zika outbreak.
Abigail Aiken, M.D., Ph.D., an assistant professor at UT Austin's LBJ School of Public Affairs, has published a study in the New England Journal of Medicine on how those advisories have impacted abortion rates and the lives of pregnant women. Since the advisories were issued, there’s been an increase in requests for abortions; but in many of these countries, abortion is either illegal or highly restricted.
“The UT System is leading the way on multiple fronts to knock out this virus.”
David Lakey, M.D.,
UT System's Chief Medical Officer
UT Austin Biology Professor David Herrin, Ph.D., wants to stop the virus by attacking its host, the Aedes mosquitos.
Herrin is combining algae with a bacterium that attacks mosquitos in places such as ponds, where their larvae grow. Right now, only the bacterium attacks the guts of mosquitos and certain flies, but Herrin is working to modify the algae so that it attacks the Aedes and Culex mosquitos, the latter carries other infectious diseases such as the West Nile virus.
Mosquito testing kit
UT Austin students are also getting involved in the Zika fight.
Undergrads from the Freshman Research Initiative are working under the leadership of UT Austin molecular biosciences professor Andy Ellington, Ph.D., to create a cheap and simple hand-held device for the public to test mosquitos in their own backyards for Zika. The do-it-yourself device requires little technical knowledge and would produce results in 45 minutes by testing dead mosquitos.
“This is a really quick and efficient way of being able to identify whether or not a mosquito is carrying a virus,” said Nicole Pederson, a biology major.
The do-it-yourself device requires little technical knowledge and would produce results in 45 minutes
Tracking the virus
UT System researchers are pinpointing Zika’s spread and mapping mosquito infested areas to better understand the virus’ movement.
UT Austin integrative biology professor Sahotra Sarkar, Ph.D., is projecting the global spread of Zika in 100 cities based on the prevalence of two Aedes mosquitos species. The first species, Aedes aegypti, is known to be effective at spreading the virus to humans. The second species, Aedes albopictus, is also a carrier of Zika and found in many more cities, but researchers are trying to determine whether it can spread the virus.
Meanwhile, UT Rio Grande Valley biologists Christopher Vitek, Ph.D., and John Thomas, Ph.D., are launching several projects with state and South Texas officials to pinpoint the location and density of Aedes mosquitos by locating their eggs. They are collaborating with a team of researchers from UTHealth Houston’s School of Public Health in Brownsville, led by Joseph McCormick, M.D., on the South Texas study.
Near the Mexican border, UT El Paso’s Mosquito Ecology and Surveillance Laboratory, led by Doug Watts, Ph.D., is tracking the Aedes aegypti to see if it’s carrying the virus around El Paso and studying the insect’s biology and ecology.
“If mosquito control is ever going to work, the number one priority is education,” said Watts, who has been chasing down the deadly insect since 1977. “It’ll be a never-ending profession to stay ahead of them.”
About The University of Texas System
Educating students, providing care for patients, conducting groundbreaking basic, applied and clinical research, and serving the needs of Texans and the nation for more than 130 years, The University of Texas System is one of the largest public university systems in the United States. With 14 institutions and an enrollment of more than 221,000, the UT System confers more than one-third of the state’s undergraduate degrees, educates almost two-thirds of the state’s health care professionals annually and accounts for almost 70 percent of all research funds awarded to public institutions in Texas. The UT System has an annual operating budget of $16.9 billion (FY 2016) including $3 billion in sponsored programs funded by federal, state, local and private sources. With more than 20,000 faculty – including Nobel laureates – and nearly 80,000 health care professionals, researchers, student advisors and support staff, the UT System is one of the largest employers in the state.
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