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This report describes the health status of the population of Northeast Texas, the 35-county area also referred to as the DSHS Health Service Region 4/5N. The purpose of this report is to provide a reference for stakeholders interested in promoting the health of Texans in this area and addressing geographic health disparities in Texas. This report can be used to prioritize health issues in the region, identify populations at greatest risk, guide targeted public health action, and set and monitor measurable objectives to improve the health and well-being of the Northeast Texas population. The health status of Northeast Texas is described using available population health indicators, including measures of health outcomes such as mortality rates, measures of health behaviors such as prevalence of cigarette smoking among adults, and measures of health care access such as the proportion of the population with health insurance.